Resurrection Roman Catholic Church was established by Bishop J. F. Regis Canevin, D.D. in 1909. It was carved out of territories which had been a part of St. Canice Parish, Knoxville (1892), to the north; St. Wendelin Parish, Carrick (1874), to the east; and St. Catherine Parish, Banksville (1902), - later moved to Beechview—to the west. At this time, the community of Brookline was growing exponentially, and the resident Catholic population was growing with it.

Bishop Canevin and his staff recognized the need for a new parish. As Catholics continued to build homes in Brookline, it became evident that a new parish was needed to help meet their spiritual needs. On May 3, 1909, the Diocese brought 12 lots from the West Liberty Development Company. The current Creedmoor Court (the old school building) and the Rectory now stand on that property.

Sixteen days later, Father James L. Quinn received his assignment from Bishop Canevin, and by May 25, 1909, the boundary lines had been drawn and the parish had been named. The new pastor used his own birthday as inspiration for naming the Church of the Resurrection. Father Quinn had been born on Easter Sunday, 1869.